This is a registry of Pyruvate Kinase patients to study how the disease affects different people and how it is treated around the world.
207 Studies found
Adult male and female U.S. recipients of allogeneic or autologous HSC transplants or cellular therapies are eligible to participate in the NMDP Research Sample Repository.
Men and women over 16 years old undergoing transplantation with unlicensed CBUs (cord blood units) will be enrolled. Cord blood units not meeting FDA requirements or not yet approved by the FDA may be used for transplant if the transplant is done as part of a study.
Seeking men & women over 18 years old who have a blood disorder or malignancy to investigate normal and abnormal cell growth.
Seeking people with a bleeding disorder such as Hemophilia or Von Willebrand Disease for a registry to collect health data to address the needs and challenges of people living with bleeding disorders.
Seeking adults with degenerative spondylolisthesis with lumbar spinal stenosis whose doctors have recommended back surgery to address the pressure on your spinal cord or spinal nerves
Study Of An Investigational Implant To Prevent The Discs Between Backbone Vertebrae From Being Pushed Out (Herniating)
Seeking men and women whose doctor has recommended surgery to relieve pain resulting from damage to a disc in their back being pushed out of place (herniated) for a study of an investigational device to prevent the disc from reherniating.
Seeking children aged 6 months and older with Tay-Sachs or Sandhoff disease for a study of the safety of an experimental gene therapy and whether it improves their ability to move.
Seeking adults aged 18 and older who either have Facioscapulohumeral Muscular Dystrophy (FSHD) or are healthy volunteers for a study to identify genetic biomarkers for the disease and better understand what causes it, and why symptoms vary widely among people who have it.
This study is looking at a preventative medication for patients at risk of developing rheumatoid arthritis.
Seeking Men and Women 18 years or older who are having an operation that will require the creation of a flap of tissue (where a piece of skin/muscle is taken from one part of the body and moved to another part), or because you have a traumatic degloving injury (an injury where the skin is torn away from the tissue underneath).
Seeking Men and Women 18 years or older who have completed a Gilead sponsored filgotinib parent study for RA GS-US-417-0303 for the treatment of Rheumatoid Arthritis (RA),
Seeking adults with Ankylosing Spondylitis, a chronic disease that causes bones in the hip and spine to erode, for a study of the effectiveness of an investigational drug in treating the disease
This study is intended to collect data from medical records on patients who have Duchenne Muscular Dystrophy
Study Of An Experimental Dietary Supplement To Improve Omega-3 Dietary Deficiency For People With Lupus
Seeking adults with Systemic Lupus Erythematosus (SLE) for a study of an experimental dietary supplement to replenish omega-3, an essential nutrient that helps to prevent and manage heart disease.
Seeking adults who have inflammatory arthritis and who are willing to provide data by answering questionnaires, giving a blood sample and donating leftover tissue samples for a study to help researchers better understand inflammatory arthritis.
Seeking men and women whose broken arms or legs will need to be treated with surgery for a study of what treatment practices best prevent infection.
Seeking boys with Duchenne Muscular Dystrophy for a study of an investigational gene therapy drug.
Seeking boys between the ages of 8 and 16 with Duchenne Muscular Dystrophy who are unable to walk 10 meters in 10 seconds for a study of an investigational drug.
Seeking boys and men with Duchenne muscular dystrophy (DMD) or Becker Muscular Dystrophy (BMD) to provide samples including blood, plasma, serum, urine, as well as the remainders of tissue samples collected as part of their usual clinical care for a biorepository.
Seeking young men aged 12 and older living with Duchenne Muscular Dystrophy (DMD) who are not able to walk and have been on a stable dose of corticosteroids for at least 6 months for a study of an investigational drug.
Seeking boys between the ages of 6 and 12 with Duchenne Muscular Dystrophy (DMD) who can walk for a study of the effectiveness and safety of an investigational drug.
This is a registry to collect medical record information from people living with Multiple Sclerosis (MS) to better understand the disease and develop new treatments
Seeking men and women with Multiple Sclerosis for a study of the role of stress in multiple sclerosis and whether an 8-week mindfulness-based stress reduction (MBSR) program effects your sense of well-being, stress level, and how it may change your brain.
Questionnaire Study Of The Long-Term Safety And Effectiveness Of The Drug Tecfidera For Multiple Sclerosis (Ms)
To collect data on patient who are receiving dimetyl fumarate as part of their routine care for multiple sclerosis
Seeking patients with a brain aneurysm (a bubble in the wall of a vessel in your brain) who, with their doctor, decided to treat it using approved endovascular coils (thin metal springs that stay in the blood vessels in the brain).
Seeking Men and Women 18-90 years old who have a small ruptured or un-ruptured aneurysm in the head.
This study is looking at an experimental treatment for patients diagnosed with a stroke caused by a blockage in the blood vessels within the brain.
Seeking patients who have suffered a brain injury like ischemic stroke, intracerebral hemorrhage or subarachnoid hemorrhage for a study of an investigational medical device to prevent fever while in the hospital
Newly diagnosed (within 6 months) people with Multiple Sclerosis (MS) sought for a trial comparing "first line" (traditional) with "second line" (aggressive) treatments in preventing disability. This is a pragmatic trial which means that even though participants will be randomly assigned a treatment group, they and their doctor can change their treatment if needed.
Seeking men and women with a brain aneurysm treated with a medical device called a Flow Diverter to slow the flow of blood into the aneurysm to see how well a software helps a doctor predict if the aneurysm will get smaller and blood flow becomes fully blocked over a year.
Seeking Ischemic (caused by reduced blood flow by narrowed or blocked arteries) stroke survivors aged 45 and older for a study of an investigational therapy using anticoagulant drugs (aspirin or apixiaban) for the prevention of another stroke
People who have been or will be treated with the Embotrap II device to remove blood clots to try to restore blood flow to the brain are being asked to participate in the EXCELLENT registry. This registry will collect and analyze the blood clots removed from the brain with the Embotrap II to study the different types of clots that cause stroke.
Seeking men and women who are within the first few hours of experiencing an ischemic stroke (caused by a blood clot blocking blood flow to the brain) for a study comparing medication combinations to reduce the impact of the stroke.
This study is enrolling men and women who have had a traumatic brain injury in order to compare outcomes when medical care is delivered based on either monitoring the pressure in the brain or monitoring both the pressure in the brain and the amount of oxygen in the brain.
Seeking men and women whose multiple sclerosis has not responded well to previous treatment and whose doctor has decided to start treatment with cladribine tablets and stop treatment with an injectable drug.
Seeking men and women with relapsing multiple sclerosis whose doctors has decided to start treatment with clabridine tablets because other pills were not working well.
Seeking volunteers who will have their brain aneurysm treated using a coil to prevent it from bursting for a study of the long term performance of the coil.
Seeking men and women with multiple sclerosis for a study of an investigational drug for multiple sclerosis. This drug has not been tested in humans before.
Seeking women and men who have started ocrelizumab treatment for their Multiple Sclerosis (MS) within the past month or people whose MS is being being treated with therapies other than ocrelizumab for a study looking at the incidence of cancer in the future.
Seeking men and women with Amyotrophic Lateral Sclerosis (ALS) who have decided with their doctor to start taking the drug Edaravone to slow their symptom progression for a study of what changes happen in the blood and urine after they start taking the drug.
Seeking men and women who are experiencing acute ischemic strokes caused by a blood clot blocking blood flow to a major artery in their brain for a study of an investigational device to remove the blood clot.
Seeking men and women aged 18 and older diagnosed with a cerebrovascular saccular aneurysm (also known as a berry aneurysm) in their head for a study of an investigational MRI imaging technique.
Study Of An Investigational Stem Cell Transplant For Treatment Resistant Relapsing Multiple Sclerosis
Seeking men and women whose multiple sclerosis has remained active despite treatment for a study comparing blood stem cell transplantation to other available treatments for multiple sclerosis.
Seeking men and women aged between 18 and 80 for a study of how the brain works when making decisions when the answer is uncertain.
Study Of Multiple Investigational Drugs To Prevent Progression Of Amyotrophic Lateral Sclerosis (Als)
Seeking men and women with Amyotrophic Lateral Sclerosis (ALS) to participate in a research trial to test several different investigational treatments.
Seeking men and women with multiple sclerosis for a study of how common sleep apnea is and whether sleep apnea affects MS symptoms.
Seeking people with Parkinson's disease and healthy volunteers for a study of how speech changes depending on PD symptoms, effects of medication and genetics.
Seeking men and women who are participating in the ARCADIA stroke prevention trial for a study of the effect of the study drugs Apixaban and Aspirin on the occurrence of silent strokes and memory loss.
Seeking people who been diagnosed with Multiple Sclerosis (MS) or a similar immune disorder of the central nervous system or their immediate family members for a study to better understand what causes these diseases and perhaps improve treatment.
Seeking men and women aged 50 and older who have had bleeding in the brain (brain hemorrhage) for a study comparing continuing or stopping statin drug use treatment on the risk of having another brain hemorrhage.
Seeking men and women whose stroke has been or will be treated with a medical device to remove the blood clot from the artery in their brain for a study observing their recovery.
Seeking men and women with relapsing multiple sclerosis for a study of how effective and safe an investigational drug is compared to the usual treatment.
Seeking people diagnosed with a motor neuron disease such as ALS or muscular dystrophy or a family member of someone with a neuromuscular disease for a study of genetic and environmental risk factors for the disease.
Seeking male & female patients who have been diagnosed with rhabdomyosarcoma (cancer that forms in the soft tissues, such as muscle).
Seeking male and female children ranging from 0-18 months of age diagnosed with non-high risk neuroblastoma.
This study is looking at using different experimental treatment methods for children diagnosed with Acute Myeloid Leukemia (AML) and Down Syndrome (DS) based on how well they respond to their first treatment.
This study is for patients who may have neuroblastoma, a tumor of nerve cells typically found in the stomach, chest or neck of young children. This is a data and sample collection study to help us better understand this disease.
Seeking Male and Female age 0-25 years who may have cancer or another condition that is characterized by abnormal cell growth but may be benign (not cancer), or may already have been diagnosed with cancer.
Seeking Male & Female patients age 0-30 years who have a kidney tumor (an abnormal growth of cells or tissues in the kidney that may be benign or malignant) or a tumor outside the kidney called a malignant rhabdoid tumor or an extrarenal Wilms tumor.
We are studying how well active surveillance, or two different combinations of chemotherapy work in treating children 11 and older and adults under age 25 with germ cell tumors.
Volunteers who are participating in the NMTRC014 research study for treatment of neuroblastoma survivors who are in remission are sought for a research study of how the study drug is absorbed into the the body.
Seeking people aged 3 to 25 with newly-diagnosed high-grade glioma whose brain tumor has been genetically tested to show that it does not have the H3, K27M and BRAF mutations for a study of an investigational drug. The study will compare whether adding the investigational drug to radiation and maintenance therapy is better than the usual treatment.
Study Of An Investigational Drug For Relapsed Or Refractory Cd22+ B-Acute Lymphoblastic Leukemia (B All)
Seeking children and young adults whose CD22+ B-Acute Lymphoblastic Leukemia (B ALL) has come back (relapsed) after treatment or has not responded (refractory) for a study of an investigational drug. While the investigational drug has been approved for use adults with leukemia, it has not yet been approved for use in children.
Seeking men and women who are or have been smokers and are at greater risk for lung cancer for a study to improve lung cancer screening
Study Of Chemotherapy For Children And Young Adults With High-Risk B-Cell Acute Lymphoblastic Leukemia (B-All)
Children and young adults up to age 25 with High-Risk B-cell acute lymphoblastic leukemia (B-ALL) sought for a study of an investigational drug in combination of chemotherapy based on individual disease characteristics to improve 5-year disease-free survival (DFS).
Seeking children and young adults 31 years old or younger who have been newly diagnosed with standard risk B-cell Acute Lymphoblastic Leukemia (B-ALL), Down syndrome B ALL or localized B-cell Lymphoblastic Lymphoma (B-LLy) for a study of chemotherapy.
Study Of An Investigational Drug Given Alone Or In Combination With A Standard Treatment For Myelofibrosis
Seeking men and women with myelofibrosis bone marrow cancer for a study of an investigational drug given alone or in combination with a standard treatment.
Seeking adult men & women whose tumor cells have a change in a gene called ALK that causes the cells to grow and spread.
This study is collecting tumor tissue, body fluids and blood samples from patients undergoing biopsies or surgery to gain a better understanding of different cancers.
This study is looking to compare different surgical options for treating patients with rectal cancer.
Seeking adults with rectal cancer requiring surgery for a study comparing an investigational surgery to the standard surgery technique
Volunteers with advanced prostate cancer that has spread to their bones sought for a study of an investigational drug to assess if it stops the cancer from growing
Seeking adults with non-small cell lung cancer for a study comparing immunotherapy to targeted therapy based on tumor characteristics
Seeking women whose ovarian cancer has returned following treatment for a study adding an investigational drug to the usual chemotherapy to see if it is better, the same or worse at extending life than the usual treatment alone.
Study Of An Investigational Drug For Metastatic Prostate Cancer That Is Resistant To Hormone Treatment
Seeking men whose prostate cancer has spread beyond their prostate despite treatment with androgen deprivation therapy (also known as castration resistant prostate cancer) for a study comparing the usual treatment to the usual treatment with an experimental drug on controlling the cancer.
We are seeking people whose liver cancer was removed through surgery and radiation therapy for a study of an investigational drug to assess if it prevents the cancer from returning
We are studying whether combining an investigational drug with standard chemotherapy and surgery is more effective than just the standard chemotherapy and surgery in treating bladder cancer.
Study Of Immunotherapy Alone Or In Combination With Chemotherapy For Advanced Nonsquamous Non-Small Cell Lung Cancer
Non-squamous non-small cell lung cancer patients whose cancer has been tested to be PD-L1 positive (a kind of tumor marker) sought for study comparing two usual approaches to treatment.
Seeking men and women aged 18 and older whose colon, peritoneal, or rectal cancer will be treated with surgery (resectable) for a study of an investigational drug to make the cancer cells glow under infrared light.
Addition Of An Investigational Drug To The Usual Treatment For Limited Stage Small Cell Lung Cancer (Ls-Sclc)
Men and women with limited-stage small cell lung cancer, which has not spread outside of their chest area sought for a study comparing how cancer responds when adding an investigational drug to the usual treatment for small cell lung cancer
Men and women with advanced HPV throat cancer sought for a study comparing the outcomes for people who get chemotherapy and radiation followed by experimental immunotherapy to those who get chemotherapy and radiation followed by observation.
Seeking men and women with pancreatic cancer for a study of an experimental device used along with chemotherapy to evaluate whether it decreases cancer cell growth.
Seeking men and women with locally advanced pancreatic cancer that can't be completely removed with surgery for a study of an investigational drug added to the standard chemotherapy.
Seeking men and women who have been diagnosed with melanoma skin cancer and will have surgery to remove it for a study of whether starting the experimental drug before surgery is better or worse than starting the drug after surgery.
Study Of The Addition Of An Investigational Drug To Treatment Following Stem Cell Transplant For Multiple Myeloma
Seeking men and women who have had stem cell transplant for their multiple myeloma for a study of an investigational drug to be added to the usual maintenance treatment.
Seeking women with advanced high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers with high folate-receptor-alpha expression for a study comparing an investigational drug to chemotherapy.
Seeking men and women with cancer of the esophagus or gastric junction for a study of whether a blood sample analyzed to find evidence of a cancer tumor (liquid biopsy) might be a useful tool to predict how well the cancer has responded to treatment.
Study Of The Safety And Efficacy Of An Investigational Drug For Inoperable Early Stage Non Small Cell Lung Cancer
Seeking men and women with early stage (I/IIA) non small cell lung cancer that can't be removed with surgery for a study of an experimental drug.
Seeing men and women whose renal cell cancer has spread to their bones for a study of an investigational drug combination to reduce pain.
Seeking women diagnosed with low-grade serous cancer of the ovary or peritoneum for a study of an investigational drug to reduce the risk of the cancer progressing or returning.
Study Adding An Investigational Immunotherapy To Standard Treatment For Locally-Advanced Non-Small Cell Lung Cancer
Seeking men and women diagnosed with locally-advanced non-small cell lung cancer that can't be treated with surgery for a study of adding an investigational immunotherapy to the standard cancer treatment.
Seeking women with ovarian cancer that progressed after at least 4 cycles of treatment with platinum-based chemotherapy for a study of an investigational drug.
Study Of An Investigational Drug Combination For Advanced Ovarian, Fallopian Tube Or Peritoneal Cancer
Seeking women with advanced ovarian, fallopian tube or peritoneal cancer who have, or will have "debulking" surgery to remove as much of their cancer as possible for a study of an investigational drug given in combination with the usual post-surgery chemotherapy with paclitiaxel and carboplatin.
Seeking men and women whose metastatic non-small lung cancer (NSCLC) has progressed after platinum doublet chemotherapy and immunotherapy for a study of an investigational drug combination.
Seeking men and women whose non-squamous non small cell lung cancer (NSCLC) has progressed after chemotherapy for a study of an investigational drug alone or in combination with an immune drug compared to the usual chemotherapy treatment.
Seeking men and women with HER2-positive breast cancer for a study comparing the usual multi-drug chemotherapy to a single chemotherapy drug and HER-2 therapy.
Seeking men and women at risk for pancreatic cancer due to family or personal history willing to participate in an detection and prevention study.
Seeking men and women who have non-small cell lung cancer removed and the cancer tumor has a change in the gene called the PD-L1 gene for a study of an investigational immunotherapy drug added to the usual chemotherapy.
Seeking men and women scheduled for MRI imaging for a clinical breast exam for a study comparing two dyes injected to enhance MRI images.
Seeking men and women whose non-small cell lung cancer responded or remained stable to platinum-based chemotherapy and are currently taking pembrolizumab for a study of an investigational drug combination for maintenance therapy.
Seeking men and women over the age of 70 whose pancreatic cancer has spread to other parts of their body for a study comparing two different drug combination therapies.
Seeking men and women aged 18 and older with colon or rectal cancer than has spread to other parts of their body (metastatic) for a study of an investigational drug added to the standard chemotherapy treatment.
Seeking men and women with cancer (breast, head and neck, squamous cell carcinoma, lymphoma, pancreatic, liver, colon, lung, bile duct, chordoma of sacrum, or sarcoma) that has not responded to chemotherapy (refractory) for a study of an investigational drug.
Study Of An Investigational Drug Combination For Initial Treatment For Metastatic Non-Small Cell Lung Cancer
Seeking men and women whose non-small cell lung cancer (NSCLC) has spread outside the lungs, and has a change in the gene called EGFR (epidermal growth factor receptor) and has not yet been treated for a study of an investigational drug combination.
Seeking men and women whose non-small cell lung cancer has spread or stopped responding to treatment and whose cancer has been tested and found to have a specific mutation in the KRAS gene known as KRAS (G12C) for a study of an investigational drug for targeted treatment against the KRAS (G12C) mutation.
A Study Of An Experimental Physical Activity And Healthy Eating Program For Children With Intellectual Disabilities
Seeking children aged 12 to 16 years old with intellectual disabilities for a weekly after school experimental program teaching physical activity and healthy eating.
Investigational Drug To Treat Social Behavior And Communication Deficits In Children With Autism Spectrum Disorder
Seeking children aged 5-17 years with an Autism Spectrum Disorder (ASD) for a study of the safety and effectiveness of investigational drug to treat social behavior and communication deficits.
Seeking teens aged 15-18 years old who were enrolled in the ELGAN study of premature infants between April 2002 and August 2004 for a follow-up study of health and developmental progress.
Seeking children aged between 3-10 years (up to 11 for boys) with pediatric growth hormone deficiency for a study comparing an investigational drug taken by mouth to the usual treatment given by daily injections.
We are collecting data and biological samples from people with infectious or inflammatory conditions of the bowel such as celiac disease, colitis, and Inflammatory Bowel Disease (IBD) and from people who do not have bowel disease to get a better understanding of these diseases.
Seeking people whose recurrent Clostridium difficile (C. diff) infection has not responded to standard antibiotic treatments for a study to see if fecal microbiota transplantation is effective for treating C. diff infection.
Seeking men and women who are experiencing recurring fluid buildup in their abdomen due to liver cirrhosis for a study of an implanted investigational device to drain the excess fluid.
Study To Reduce The Risk Of Clostridium Difficile (C-Diff) Infection Among Long-Term Care Facility Patients
Seeking men and women aged 65 and older for a study of changes in the microbiome in the intestines of seniors when they move into a long-term care facility.
This research is collecting data on nicotine cravings in patients with chronic pancreatitis who smoke cigarettes.
Seeking Men and Women 18-65 years old who have a fistula-in-ano that needs treatment.
Reverse: A Study Of An Investigational Drug For Compensated Cirrhosis Due To Nonalcoholic Steatohepatitis (Nash)
Nonalcoholic Steatohepatitis (NASH) results when fat accumulates in the liver and causes inflammation and scarring called fibrosis. Fibrosis can lead to cirrhosis which impairs liver function. Ocaliva (OCA) is an FDA approved drug for treating another type of liver disease. This study will test if Ocaliva (OCA) is safe and effective in treating cirrhosis of the liver caused by advanced NASH.
This study is looking at an investigational treatment for patients who have been diagnosed with or have signs and symptoms of moderately to severely active Crohn’s disease.
This study is for patients diagnosed with moderately to severely active Crohn’s disease who have recently completed research study Receptos-3201 or Receptos-3202.
This study is for patients diagnosed with moderately to severely active Crohn’s disease who have recently completed a research study with the study drug.
Study Of An Investigational Therapy Using Stem Cells For Perianal Fistulas In People With Crohn's Disease
People whose perinanal fistula resulting from crohn's disease has not healed with treatment sought for a study of an investigational therapy using stem cells.
People who have shown signs of bleeding in their stomach or intestines sought for a study of a video camera capsule to diagnose gastrointestinal bleeding.
Seeking healthy volunteers who either drink less than 1 drink per week on average or at least 3 drinks per day for a study collecting biological samples (blood, urine, and stool) and health information to better understand alcoholic hepatitis.
Seeking men and women who will be undergoing abdominal surgery to remove part of their bowel (bowel resection surgery) for a study of an investigational drug to improve bowel function after surgery. We hope that the investigational drug will prevent a condition called postoperative ileus (POI) or postoperative gastrointestinal dysfunction (POGD).
Seeking men and women for whom their doctor has ordered an upper endoscopy to diagnose upper gastrointestinal symptoms for a study of an investigational imaging device.
Children and adults who either have macular degeneration or are closely related to someone who has macular degeneration are sought for a study of macular degeneration and other related ocular disorders to prevent visual loss and blindness for current and future generations
Study Of An Investigational Drug For Geographic Atrophy Associated With Dry Age-Related Macular Degeneration
Seeking men and women with an eye condition called geographic atrophy (GA) secondary to dry age- related macular degeneration (AMD) for a study of an investigational drug.
Seeking adult men and women who have heart failure and are at risk of having episodes of worsening heart failure for a study of an implanted heart pressure sensor.
Stroke survivors aged 50 and over sought for a study to develop and test a wearable sensor to monitor for atrial fibrillation (abnormal heartbeats)
Study Of The Differences Between People Having A Heart Attack And People Suffering Stress Cardiomyopathy
Seeking men and women who are experiencing symptoms of a heart attack including chest pain and shortness of breath for a study of the effect of stress on heart function and the development of stress cardiomyopathy.
Seeking men and women who are at least 70 years old for a study of whether screening for atrial fibrillation or atrial flutter using an investigational wearable device helps reduce the risk of stroke.
Seeking men and women with heart failure or who have had a heart attack to be interviewed for a study to develop a program that uses peoples experience of chest pain to plan for discharging cardiac patients from the hospital.
Seeking adult patients whose doctor has ordered a test called a Cardiac Catheterization to check for and possibly fix blockages in the heart. The doctor performing the cardiac catheterization will decide which patients who volunteer for the study are suitable participants.
Seeking men and women over the age of 18 who have been diagnosed with an aortic aneurysm (bulging of the vein that carries blood to your heart) that because of their anatomy can't be treated using an FDA-approved graft. This study would use endografts that are customized by the doctor to the anatomy of each patient to treat these complex aortic aneurysms.
Seeking men & women 18 years old and over who have a cardiomyopathy (impairment of your heart muscle strength) from coronary artery disease (hardening of the arteries).
Seeking men and women whose carotid arteries have narrowed for a study of an intense medical management plan to reduce risk factors for stroke including high blood pressure, high cholesterol, diabetes, and smoking.
Seeking men and women who are within 10 hours from the time they started to have stroke symptoms for a study of how well people who get the investigational drug in additional to the usual treatment recover compared to people who get a medicine without any active drug (placebo) in addition to the usual treatment.
Seeking men and women diagnosed with severe aortic valve stenosis for a study of an investigational device to replace the aortic valve.
Volunteers who are at risk for having heart disease, taking aspirin, and will be or have already undergone a cardiac catheterization sought for a study of how the body makes blood clots and its effect on the risk for heart attack and stroke.
Seeking men and women who are about to start a taking a pill to help thin their blood (called an anticoagulant) for a study of whether adding a clinical pharmacist to the study team improves care.
Study Of An Investigational Drug To Prevent Blood Clots And Elevated Blood Pressure In People With Heart Disease
Seeking adults with heart disease who are taking an aspirin to prevent blood clots from forming for a study of an investigational drug to assess if it prevents cells other than platelets from making thromboxane, a natural molecule made by your body to help blood to clot.
Seeking men and women whose doctor has recommended an ablation procedure to treat their paroxysmal atrial fibrillation for a study of an investigational device.
Study Of An Investigational Device To Remove Blood Clots For People Who Are Experiencing An Ischemic Stroke
Seeking men and women experiencing an ischemic stroke caused by a blood clot blocking blood flow to a part of the brain and causing a large amount of brain damage for a study comparing treatments to remove the blood clots.
Seeking men and women who will be undergoing a medical procedure to remove a blood clot or blockage from an artery that is blocking blood flow to the brain (ischemic stroke) for a study of the technical use and safety of a device used during the procedure.
Study Of An Investigational Device To Remove Blockage From Blood Vessel In Brain Causing Ischemic Stroke
Seeking men and women who are within 8 hours of having an ischemic stroke caused by a blockage or clot of a blood vessel in the brain for a study of an investigational device to remove the clot.
Seeking adults and children who will be getting treatment at UMass for cerebralvascular diseases to participate in a registry to collect information that could improve treatment decisions.
Seeking men and women with peripheral artery disease (PAD) causing pain in the legs when walking or climbing stairs for a study of an investigational dietary supplement combination to improve blood flow.
Seeking blood samples from healthy volunteers and volunteers who have various autoimmune diseases, like type 1 diabetes
Seeking men and women who are willing to donate fat cells for a study of the difference between fat cells collected from healthy volunteers and people who have type 2 diabetes.
Seeking men and women with type 2 Diabetes Mellitus to participate in an expert panel for a study to develop and test a technology to help people manage their diabetes.
Study of whether treatment of congenital cytomegalovirus (cCMV) in infants who have experienced hearing-impairment reduces the loss in left or right ear hearing.
Seeking healthy adults and adults who have been suffering influenza-like illness for no more than 14 days for a study of how the flu or flu-like infections affect their blood cells.
Seeking children who have been diagnosed with influenza in the past 7 days and healthy children willing to donate a blood sample for a study of how influenza affects blood cells of children.
Study Of An Investigational Drug For An Upper Respiratory Tract Infection Caused By Respiratory Syncytial Virus (Rsv)
Seeking men and women who have had a bone marrow transplant and have an upper respiratory tract infection caused by respiratory syncytial virus (RSV) for a study of an investigational drug.
Seeking people, local to central Massachusetts, who are fully recovered from the new coronavirus to sign up to donate plasma to help current COVID-19 patients.
Seeking emergency room healthcare providers at UMass for a study of risk factors for COVID-19.
Seeking people aged 12 and older who have been diagnosed with COVID-19 for an experimental treatment made from blood donated by people who have recovered from COVID-19.
Seeking boys and girls under the age of 18 who are hospitalized for a COVID-19 infection for a study of the safety and effectiveness of remdesivir for COVID-19 infection in children.
Study Of The Safety And Efficacy Of Investigational Monoclonal Antibodies For Mild To Moderate Covid-19 (Blaze-1)
Seeking individuals over 12 years of age with mild to moderate COVID-19 illness, but have not yet been hospitalized for a study of investigational monoclonal antibodies against COVID-19.
Study Of An Investigational Drug To Prevent Hospitalization For People Newly Diagnosed With Covid-19
Seeking men and women who have tested positive for COVID-19 within the past 10 days and within 7 days of first experiencing COVID symptoms for a study of an investigational drug.
Seeking men and women who have been hospitalized for moderate to severe COVID-19 for a study to evaluate whether adding one of several different immune modulators to standard care with remdesivir improves recovery from illness.
Study Of An Investigational Drugs Containing Monoclonal Antibodies For Mild To Moderate Covid-19 (Blaze 4)
Seeking men and women with mild to moderate COVID-19 for a study of an investigational drug that contains monoclonal antibodies.
Seeking men and women who have been hospitalized with COVID-19 for a study that compares the safety and activity of experimental regimens consisting of oral anti-inflammatory agents plus Remdesivir.
Study Of An Investigational Drug To Reduce Virus And Prevent Inflammation In Hospitalized Covid-19 Adults
Seeking men and women who have been hospitalized for COVID-19 and are within one week of first experiencing COVID-19 symptoms for a study of an investigational drug to reduce the virus and prevent inflammation.
Seeking people willing to provide samples such as nasal swabs, or blood, answer questions about their health, and allow their medical record to be followed for a number of studies about to better understand the COVID-19 virus.
Seeking men and women with mild to moderate COVID-19 infection who have tested positive within the last 3 days for a study of an investigational drug that has been approved for use in other countries for the flu and other viral illnesses.
Seeking people previously diagnosed with COVID-19 willing to donate a blood sample for a study of immune responses to the COVID-19 virus.
Seeking men and women willing to provide additional nasal, saliva and blood samples when being tested for COVID-19 for a biorepository to support development of tests for COVID-19 and studies of how COVID-19 causes disease in people.
Seeking men and women aged 18 and older who have not had COVID-19 or been vaccinated for a study of an investigational device used at home to detect COVID-19 in nasal swabs.
Seeking healthy children younger than 12 for a study of an investigational vaccine against COVID-19.
Seeking adults and children for a study testing the accuracy of investigational devices to diagnose COVID-19.
Seeking men and women aged 50 and older hospitalized with pneumonia caused by a COVID-19 infection for a study of the long-term effects of COVID-19 on memory and thinking.
Seeking men and women with either normal airways or airways that have been difficult to manage while under anesthesia for a study of a voice test might reliably predict people whose airways may be difficult to manage during an operation.
Seeking intubated (tube placed in someone's throat to help them breathe) people for a study of an investigational device to improve their communication with caregivers.
Study Of Body Fluid Samples From People With Cystic Fibrosis To Look At The Body's Response To Infection\ Inflammation
Seeking people with Cystic Fibrosis aged 12 and older for a study of blood, sputum, and/or leftover fluid collected during your bronchoscopy to look at how your body responds to infection or inflammation.
Seeking men and women who are current smokers for a study of motivational text messages to help people stop smoking.
This is an observational study of patients with cystic fibrosis. Any patient diagnosed with cystic fibrosis can participate.
Preterm Infants diagnosed with pauses in breathing (apnea of prematurity) and treated for intermittent hypoxia using caffeine sought for study of longer-term caffeine treatment
Study Of An Investigational Drug On Growth And Pubertal Development In Children With Cystic Fibrosis
Seeking children aged 5-16 years old who have cystic fibrosis for a study an investigational drug that has been shown to improve lung function and may also improve growth and pubertal development.
Seeking men and women who have been diagnosed with schizophrenia or schizoaffective disorder and a substance use disorder for a study of an anti-psychotic medication to see it helps reduce substance cravings.
Seeking men and women who have been diagnosed with schizophrenia or schizoaffective disorder for a study of an investigational drug for negative symptoms, which are thoughts, feelings, or behaviors normally present that are absent or diminished in people with schizophrenia or schizoaffective disorder.
Study comparing two interventions to reduce suicidal behaviors and thoughts for people admitted to the emergency department or psychiatric unit of the hospital who recently attempted suicide or had suicidal thoughts
Men and women who arrive at the emergency department seeking care for either a medical or psychiatric condition may be asked to participate in a study of a screening survey to identify people at risk for suicide.
Seeking deaf adults and ASL users who is experiencing problems with alcohol use and trauma for an experimental intervention that we hope will reduce symptoms of addiction.
Seeking veterans with post-traumatic stress disorder (PTSD) or PTSD symptoms for a study of an intervention to see if observing and caring for injured or orphaned wildlife at a wildlife rehabilitation center helps to reduce PTSD symptoms.
Seeking men and women who have been treated in the Emergency Department following a traumatic event or injury for a study to learn more about the recovery process.
Seeking teens who live with Autism Spectrum Disorder (ASD) for a study to image their brains using magnetic resonance imaging (MRI) to better understand how their brains function.
Adults currently suffering from symptoms of post-traumatic stress disorder are invited to participate in a research study to determine the effectiveness and safety of an investigational drug for post-traumatic stress disorder (PTSD).
This study is collecting tissue and information from pregnant women who are having cesarean births to gain a better understanding of how the uterus functions.
Pregnant women who are in their late 2nd to 3rd trimester who have high blood pressure are sought for a study to develop a screening test for preeclampsia in pregnant women. We will collect samples of your blood, urine, and saliva to see if we can detect levels of a protein that would help accurately predict who will get preeclampsia.
Pregnant women with either normal or high blood pressure sought for a study of the effects of high blood pressure during pregnancy. The study will assess whether future cardiovascular disease or serious pregnancy complications like preeclampsia can be better detected & prevented.
Seeking pregnant women with chronic hypertension, gestational hypertension or a history of hypertensive disorders of pregnancy for a brief survey of their experiences and approaches to healthy eating.
Looking for adult volunteers 18 years of age or older with no history of any chronic skin diseases for a research study using clinical patch testing to see their skin’s response to chemical allergens.
We are studying how skin diseases occur in the skin, including how immune cells choose to initiate disease as well as what causes them to enter the skin.
We are collecting skin and blood samples from people with autoimmune or inflammatory skin diseases, like vitiligo psoriasis, atopic dermatitis, or scleroderma and from healthy volunteers to study how these skin diseases start in immune cells and why they affect the skin
Seeking children and adults with an autoimmune skin disease such as vitiligo, atopic dermatitis, alopecia areata, lupus, psoriasis, or scleroderma, and adult healthy volunteers willing to donate skin and blood for a study of autoimmune diseases of the skin.
Seeking people of all ages to participate in an observational study of immune-mediated skin diseases like Atopic Dermatitis, Psoriasis, Alopecia, Vitiligo, Hidradenitis Suppurativa and others. In this type of study we look at your medical history, but do not change the way you are being treated by your doctor.
Seeking men and women with stable vitiligo for a study of an investigational device for transplanting healthy skin cells to return skin color to areas that have lost their pigmentation due to stable vitiligo.
Seeking men and women who take blood thinning medication and who will have Mohs surgery to remove skin cancer cells for a study of an investigational drug to reduce bleeding during surgery.
Seeking men and women with a skin condition called atopic dermatitis, which is a more severe type of eczema, for a study of a skin biopsy sampling technique called microsampling.
Seeking men and women with vitiligo for a study of an investigational device to inject healthy skin cells into areas of skin that have lost color due to vitiligo.
Seeking men and women with or without an inflammatory skin disease ( such as cutaneous lupus erythematosus, dermatomyositis, atopic dermatitis, alopecia areata, scleroderma, eczema, psoriasis, vitilago, or drug hypersensitivity) for a study to learn more about skin diseases and their response to light.
Adults aged 50 and older who have a planned abdominal, urologic, or other major surgery sought for a study on whether completing a walking exercise program before surgery improves surgical outcomes.
Seeking men and women who are planning spinal fusion surgery for a study comparing two methods of post-operative pain management.
Study Of An Investigational Drug To Improve Pain Management Following Total Shoulder Replacement Surgery
We are seeking men and women who will be undergoing total shoulder replacement surgery for a study comparing post-surgery pain between people who have the investigational drug added to the usual nerve block to people who just have the usual nerve block.
Seeking men and women who will be undergoing surgery or being cared for in an intensive care unit and who will require an intra-arterial catheter for a study of a investigational device similar to a wristwatch to continuously monitor blood pressure.
Seeking men and women aged 65 or older who have been discharged from the hospital within the past month for a survey of their health and use of healthcare following their discharge from the hospital.