Seeking adult men and women with HER2 positive breast cancer who have already received treatment to determine if a combination of different drugs is better than the usual treatment alone in preventing this cancer from returning.
Seeking male & female patients who have been diagnosed with rhabdomyosarcoma (cancer that forms in the soft tissues, such as muscle).
Seeking male and female children ranging from 0-18 months of age diagnosed with non-high risk neuroblastoma.
This study is looking at using different experimental treatment methods for children diagnosed with Acute Myeloid Leukemia (AML) and Down Syndrome (DS) based on how well they respond to their first treatment.
This study is for patients who may have neuroblastoma, a tumor of nerve cells typically found in the stomach, chest or neck of young children. This is a data and sample collection study to help us better understand this disease.
Seeking Male and Female age 0-25 years who may have cancer or another condition that is characterized by abnormal cell growth but may be benign (not cancer), or may already have been diagnosed with cancer.
Seeking Male & Female patients age 0-30 years who have a kidney tumor (an abnormal growth of cells or tissues in the kidney that may be benign or malignant) or a tumor outside the kidney called a malignant rhabdoid tumor or an extrarenal Wilms tumor.
We are studying how well active surveillance, or two different combinations of chemotherapy work in treating children 11 and older and adults under age 25 with germ cell tumors.
Seeking people aged 3 to 25 with newly-diagnosed high-grade glioma whose brain tumor has been genetically tested to show that it does not have the H3, K27M and BRAF mutations for a study of an investigational drug. The study will compare whether adding the investigational drug to radiation and maintenance therapy is better than the usual treatment.
Seeking children and young adults whose CD22+ B-Acute Lymphoblastic Leukemia (B ALL) has come back (relapsed) after treatment or has not responded (refractory) for a study of an investigational drug. While the investigational drug has been approved for use adults with leukemia, it has not yet been approved for use in children.
Seeking men and women aged 18 and older whose colon, peritoneal, or rectal cancer will be treated with surgery (resectable) for a study of an investigational drug to make the cancer cells glow under infrared light.
Seeking men and women who are or have been smokers and are at greater risk for lung cancer for a study to improve lung cancer screening
Children and young adults up to age 25 with High-Risk B-cell acute lymphoblastic leukemia (B-ALL) sought for a study of an investigational drug in combination of chemotherapy based on individual disease characteristics to improve 5-year disease-free survival (DFS).
Seeking children and young adults 31 years old or younger who have been newly diagnosed with standard risk B-cell Acute Lymphoblastic Leukemia (B-ALL), Down syndrome B ALL or localized B-cell Lymphoblastic Lymphoma (B-LLy) for a study of chemotherapy.
Seeking men and women who are current smokers for a study of motivational text messages to help people stop smoking.
Seeking people aged 30 and younger newly diagnosed with diffuse anaplastic Wilms tumor, a type of cancer that occurs in the kidney, for a study of experimental treatment regimen because no standard treatment regimen currently exists.
Seeking men and women who have had a lung nodule detected during imaging for collection of nasal swab and blood samples.
Seeking people aged 2-21 years who have been diagnosed with Philadelphia chromosome positive (Ph+) or ABL-class fusion positive Acute Lymphoblastic Leukemia (ALL) for a study of whether using a less toxic chemotherapy in combination with a drug called imatinib can keep the cancer from returning after treatment.
Seeking men and women who have been diagnosed since January 1, 2020, with metastatic non-small cell lung cancer and have been or will be treated with immunotherapy, chemotherapy or a combination of the two for a study to develop a tool to help guide treatment decisions.
Seeking men and women with advanced relapsed, refractory, or resistant hematological (blood) cancer with an IDH mutation that has not responded or stopped responding to prior treatment for participation in a study of an investigational drug.
Seeking men and woment 18 years of age or older who have been diagnosed with recurrent glioblastoma multiforme and who have failed standard first line therapy.
Seeking men and women with untreated metastatic anal cancer for a study on whether adding an immune checkpoint inhibitor drug to the usual chemotherapy helps prevent the cancer from getting worse.
Seeking men and women who have Myelofibrosis bone marrow cancer and are not going to have a stem cell transplant for a study of an investigational drug reduce spleen volume and improve symptoms of Myelofibrosis.
Seeking men and women newly diagnosed with untreated acute myeloid leukemia (AML) who are unable to have chemotherapy for a study of an investigational drug in combination with the standard treatment.
Seeking men and women whose meningioma (cancer of the brain covering) has gotten bigger or grew back after treatment for a study of whether cancer drugs targeting tumors based on their genetics is better, the same, or worse than the standard treatment for meningiomas.
Seeking men and women with metastatic cancer that has spread to their brain and progressed or grew back after treatment for a study of an investigational immunotherapy drug based on the gene type and source of the original cancer to prevent growth of metastatic tumors in the brain.
Seeking men and women getting chemotherapy with Carboplatin and Paclitaxel for a study of an investigational drug to prevent neuropathy.
Seeking men and women with newly diagnosed glioblastoma for a study of an investigational device used in combination with chemotherapy and radiation.
Seeking adult men & women whose tumor cells have a change in a gene called ALK that causes the cells to grow and spread.
This study is looking to compare different surgical options for treating patients with rectal cancer.
Volunteers with advanced prostate cancer that has spread to their bones sought for a study of an investigational drug to assess if it stops the cancer from growing
Seeking adults with non-small cell lung cancer for a study comparing immunotherapy to targeted therapy based on tumor characteristics
Non-squamous non-small cell lung cancer patients whose cancer has been tested to be PD-L1 positive (a kind of tumor marker) sought for study comparing two usual approaches to treatment.
Men and women with advanced HPV throat cancer sought for a study comparing the outcomes for people who get chemotherapy and radiation followed by experimental immunotherapy to those who get chemotherapy and radiation followed by observation.
Seeking men and women with cancer of the esophagus or gastric junction for a study of whether a blood sample analyzed to find evidence of a cancer tumor (liquid biopsy) might be a useful tool to predict how well the cancer has responded to treatment.
Seeing men and women whose renal cell cancer has spread to their bones for a study of an investigational drug combination to reduce pain.
Seeking men and women diagnosed with locally-advanced non-small cell lung cancer that can't be treated with surgery for a study of adding an investigational immunotherapy to the standard cancer treatment.
Seeking women with advanced ovarian, fallopian tube or peritoneal cancer who have, or will have "debulking" surgery to remove as much of their cancer as possible for a study of an investigational drug given in combination with the usual post-surgery chemotherapy with paclitiaxel and carboplatin.
Seeking men and women whose non-squamous non small cell lung cancer (NSCLC) has progressed after chemotherapy for a study of an investigational drug alone or in combination with an immune drug compared to the usual chemotherapy treatment.
Seeking men and women with HER2-positive breast cancer for a study comparing the usual multi-drug chemotherapy to a single chemotherapy drug and HER-2 therapy.
Seeking men and women at risk for pancreatic cancer due to family or personal history willing to participate in an detection and prevention study.
Seeking men and women over the age of 70 whose pancreatic cancer has spread to other parts of their body for a study comparing two different drug combination therapies.
Seeking men and women whose non-small cell lung cancer (NSCLC) has spread outside the lungs, and has a change in the gene called EGFR (epidermal growth factor receptor) and has not yet been treated for a study of an investigational drug combination.
Seeking men and women with hormone receptor positive/ human epidermal growth factor receptor 2-negative (HR+/HER2-) locally advanced inoperable or metastatic breast cancer for a study of an investigational drug combination.
Seeking men and women whose non-small cell lung cancer has spread or stopped responding to treatment and whose cancer has been tested and found to have a specific mutation in the KRAS gene known as KRAS (G12C) for a study of an investigational drug for targeted treatment against the KRAS (G12C) mutation.
Seeking men and women whose multiple myeloma has returned or has not responded to their most recent treatment for a study adding an investigational drug to the usual treatment.
Seeking women with microsatellite stable (MSS) recurrent or persistent endometrial cancer (EC) that has been treated with between one and three different types of chemotherapy for a study of an investigational drug combination to prevent the cancer from progressing.
Seeking men and women over 18 years of age who have been diagnosed with metastatic esophageal carcinoma for a study of two drugs in addition to chemotherapy as compared to the standard of care.
Seeking men and women aged 18 and older who have upper tract urothelial cancer for a study of whether adding an immunotherapy drug to the standard chemotherapy aid in preventing or delaying the cancer from growing.
Seeking men 18 years of age or older, for participation in a study of an investigational drug called Relugolix in combination with other drugs, for certain types of prostate cancer.
Seeking men and women aged 18-65 years whose large B-Cell lymphoma has not responded or come back after treatment for a study of an investigational drug combination.
Seeking men and women with with Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis with Severe Thrombocytopenia for a study of an investigational drug to reduce spleen volume.
Seeking men and women over 18 years of age who have relapsed or refratory B-cell lymphoma after first line chemoimmunotherapy for participation in a study looking at an investigational drug in combination with other drugs
IRONMAN Registry aims to collect detailed information about the participants in the study at the time of enrollment and to follow their medical care to better understand what treatments work and where there are unmet needs in their treatment.
Seeking men and women whose locally-advanced stage III Non-small Cell Lung Cancer (NSCLC) can not be treated with surgery for a study of adding an investigational drug to the standard chemoradiation therapy.
Seeking men and women 18 years of age or older, with kidney or thyroid cancer who are taking medications that help stop the spread of these cancers to look at the effects of blood pressure and blood pressure monitoring related to these medications.
Seeking men and women whose head and neck cancer has progressed following immune checkpoint inhibitor treatment for a study of an investigational drug combination.
Seeking men and women with advanced non-small cell lung cancer with a RET gene mutation for a study of adding the study drug selpercatinib to chemotherapy compared to the usual treatment.
Seeking men and women who have Multiple Myeloma (MM) and will undergo Autologous Stem Cell Transplant (ASCT) as a form of treatment for a study of an investigational drug to help collect blood stem cells.
Seeking men whose metastatic prostate cancer has responded exceptionally well to therapy that included a medication to decrease testosterone and a medication to prevent growth signals in the body from male hormones including testosterone for a study of interrupting hormone treatment to allow testosterone levels to recover.
Seeking men and women with urothelial (renal pelvis, ureter, bladder, or urethra) cancer that has spread to other places in the body (metastatic) for a study of an investigational drug combination.
Seeking women at least 18 years of age with confirmed or recurrent endometrial cancer for study of an investigational drug
Seeking male and female participants who are under 22 years of age at enrollment with newly diagnosed de novo AML (a cancer of the bone marrow) for participation in a study comparing standard chemotherapy to one or more investigational drugs.